We are independent & ad-supported. We may earn a commission for purchases made through our links.
Advertiser Disclosure
Our website is an independent, advertising-supported platform. We provide our content free of charge to our readers, and to keep it that way, we rely on revenue generated through advertisements and affiliate partnerships. This means that when you click on certain links on our site and make a purchase, we may earn a commission. Learn more.
How We Make Money
We sustain our operations through affiliate commissions and advertising. If you click on an affiliate link and make a purchase, we may receive a commission from the merchant at no additional cost to you. We also display advertisements on our website, which help generate revenue to support our work and keep our content free for readers. Our editorial team operates independently of our advertising and affiliate partnerships to ensure that our content remains unbiased and focused on providing you with the best information and recommendations based on thorough research and honest evaluations. To remain transparent, we’ve provided a list of our current affiliate partners here.

What Is Acetylation?

Andrew Kirmayer
Updated May 21, 2024
Our promise to you
All The Science is dedicated to creating trustworthy, high-quality content that always prioritizes transparency, integrity, and inclusivity above all else. Our ensure that our content creation and review process includes rigorous fact-checking, evidence-based, and continual updates to ensure accuracy and reliability.

Our Promise to you

Founded in 2002, our company has been a trusted resource for readers seeking informative and engaging content. Our dedication to quality remains unwavering—and will never change. We follow a strict editorial policy, ensuring that our content is authored by highly qualified professionals and edited by subject matter experts. This guarantees that everything we publish is objective, accurate, and trustworthy.

Over the years, we've refined our approach to cover a wide range of topics, providing readers with reliable and practical advice to enhance their knowledge and skills. That's why millions of readers turn to us each year. Join us in celebrating the joy of learning, guided by standards you can trust.

Editorial Standards

At All The Science, we are committed to creating content that you can trust. Our editorial process is designed to ensure that every piece of content we publish is accurate, reliable, and informative.

Our team of experienced writers and editors follows a strict set of guidelines to ensure the highest quality content. We conduct thorough research, fact-check all information, and rely on credible sources to back up our claims. Our content is reviewed by subject-matter experts to ensure accuracy and clarity.

We believe in transparency and maintain editorial independence from our advertisers. Our team does not receive direct compensation from advertisers, allowing us to create unbiased content that prioritizes your interests.

Most of the proteins in the human body are altered through acetylation. This process involves the addition of an acetyl radical while a hydrogen atom leaves the molecule, so an acetate is formed. It has control over protein formation, drug biotransformation, as well as the regulation of deoxyribonucleic acid (DNA) and other genetic elements, as part of a process called histone acetylation. Substances called acetyltransferases trigger the reactions that occur, and certain kinds of these have been found in people with a tendency to develop cancer and other diseases.

For acetylation to occur, N-alpha-acetyltransferases have to be present. There are three common variations of these that are labeled A, B, and C that all act within the cells to transfer molecules. They also control the proteins that build up the cellular cytoskeleton, as well as assist with DNA transcription. Proteins that replicate DNA and repair damaged genetic material are created directly by acetylation. The reaction also determines the energy that proteins use during duplication which has an effect on how accurately genes can be copied.

Copying DNA usually results in mistakes in certain parts of the segment. Parts that have errors in genetic coding are removed by proteins and the segments are later attached, but there are different ways that DNA copying can take place. Sometimes less faulty pieces are removed, while in other cases a larger percentage of the error-filled segments are taken away. There is a way acetylation is triggered by cellular proteins and when the reaction begins, chemicals are added to the DNA-controlling proteins.

Acetylation is one of the most studied processes in epigenetics. If proteins can control how DNA is replicated and the amount of damaged components that increase with age, researchers believe that the regulation of acetylation might avoid or at least delay the onset of genetic-based diseases. The aging process could be delayed as well, but as of 2011 no drug exists that can regulate the protein activity of biological molecules in this way.

Many drugs are processed in the body through acetylation, either by biotransformation into an effective compound or to be metabolized into substances that the body can get rid of easier. Up to 90% of proteins are converted or somehow controlled by the reaction. This does not occur in dogs, but in many organisms is the primary method in which proteins interact with the genome.

All The Science is dedicated to providing accurate and trustworthy information. We carefully select reputable sources and employ a rigorous fact-checking process to maintain the highest standards. To learn more about our commitment to accuracy, read our editorial process.
Link to Sources
Andrew Kirmayer
By Andrew Kirmayer
Andrew Kirmayer, a freelance writer with his own online writing business, creates engaging content across various industries and disciplines. With a degree in Creative Writing, he is skilled at writing compelling articles, blogs, press releases, website content, web copy, and more, all with the goal of making the web a more informative and engaging place for all audiences.
Discussion Comments
Andrew Kirmayer
Andrew Kirmayer
Andrew Kirmayer, a freelance writer with his own online writing business, creates engaging content across various...
Learn more
All The Science, in your inbox

Our latest articles, guides, and more, delivered daily.

All The Science, in your inbox

Our latest articles, guides, and more, delivered daily.